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M9480142.TXT
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1994-08-09
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Document 0142
DOCN M9480142
TI Is there IgA of gut mucosal origin in the serum of HIV1 infected
patients?
DT 9410
AU Quesnel A; Moja P; Lucht F; Touraine JL; Pozzetto B; Genin C; Laboratory
of Research in Immunology, University of; Saint-Etienne, INSERM, Lyon,
France.
SO Gut. 1994 Jun;35(6):803-8. Unique Identifier : AIDSLINE MED/94292010
AB This study was performed in 77 HIV1 seropositive adult patients to
characterise the IgA hyperglobulinaemia seen in the serum during the
course of HIV infection. It was shown that both IgA1 and IgA2 subclass
concentrations were simultaneously increased but the IgA1 increase was
predominant. Secretory IgA (SIgA) concentration was significantly
increased and IgA activity to gliadin, bovine serum albumin, and casein
could be detected and was correlated with SIgA concentration. In
contrast, IgA activity to cytomegalovirus and to tetanus toxoid did not
correlate with total IgA concentration. These data suggest the presence
of IgA from gut mucosal origin in the serum of these patients. Hyper IgA
was inversely correlated with the CD4+ cell number. The increase of all
parameters studied varied according to the total IgA concentration in
the serum but was also directly related to the stage of immune
deficiency in patients with hyper IgA.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Aged Antibodies,
Viral/BLOOD Antigenic Determinants/ANALYSIS Caseins/IMMUNOLOGY
Cytomegalovirus/IMMUNOLOGY Female Gliadin/IMMUNOLOGY Human
HIV-1/*IMMUNOLOGY IgA/*BLOOD IgA, Secretory/BLOOD IgG/BLOOD
Intestinal Mucosa/*IMMUNOLOGY Leukocyte Count Male Middle Age Serum
Albumin, Bovine/IMMUNOLOGY Support, Non-U.S. Gov't T4 Lymphocytes
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).